From the West/USA:

⋒ From San Diego take a 30 minute drive/ride to Cross Border Xpress (CBX), a border crossing directly into the Tijuana airport (TIJ).
An hour and twenty minute direct flight (Volaris airline flight #Y4 406) gets you to Ciudad Obregón (CEN). We can help pre-arrange ground transportation from Obregón airport to Álamos, an hour and fifteen minute drive. 
OR an hour and forty-five minute direct flight (Volaris airline flight #Y4 560) gets you to Los Mochis (LMM). We can help pre-arrange ground transportation from Los Mochis to Álamos, a 3 hour drive.

⋒ From Phoenix (PHX) to Hermosillo (HMO), an hour and fifteen minute direct flight. We will help pre-arrange ground transportation from Hermosillo to Álamos, a 4 hour drive. 

⋒ Drive down the 15! We've done it hundreds of times. Tucson is a bit of a hub for us and we travel to and from by car often. We can help arrange a shuttle to transport groups. The drive takes approximately 8 hours.

From the East/USA:

⋒ Besides the Phoenix to Hermosillo flight, when you search flights to Ciudad Obregón from anywhere in the US, the routes have layovers in Guadalajara (GDL) or Mexico City (MEX). Transportation from Ciudad Obregón to Álamos is an hour and fifteen minute drive.